How will the climate develop, how secure is our energy supply, and what chances does molecular medicine offer? The rapidly increasing amount of data offers radically new opportunities to address today’s most pressing questions of society, science, and economy: Data, outcomes and predictions are, however, subject to uncertainties. The goal of the project Uncertainty Quantification is to understand these uncertainties through methods of probability theory, and to include them into research and outreach. The project connects applied researchers from the four research fields Earth & Environment, Energy, Health, and Information among each other and with Helmholtz data science experts, as well as external university partners from mathematics and econometrics.